OBJECTIVES: The primary objectives of this study were to review and describe the profile of a subset of Filipino patients with gastric cancer, to determine the overall survival and disease-free survival according to stage, as well as the effect of surgery and different adjuvant treatments on the survival of these patients.
METHODS: Reviewed were the clinical records of 125 gastric cancer patients seen by the authors from September 1985 to June 2001 in four hospitals in Metro Manila. Of the 125 cases, 81 patients operated for gastric adenocarcinoma with a minimum of two years follow-up or with recurrence or death within two years were included.
RESULTS: The mean age of the patients was 60 years (range=27 to 82 years), with a male to female ratio of 1.4:1. The median follow-up of the patients was 14 months (range=1.5 to 131 months). The tumors were in the body of the stomach in 53 percent and 52 percent of them were poorly differentiated. Total gastrectomy was the most common operation done (30/81). The liver was the most common site of recurrence (36 percent). The 5-year overall survival rates for stage I, II, III, and IV were 100 percent, 80 percent, 30 percent and 0, respectively. Likewise the 5-year disease-free survival rates for stage I, II, and III were 100 percent, 80 percent and 42 percent, respectively.
CONCLUSION: We found that subtotal gastrectomy was associated with a significantly longer 5-year overall survival (p=0.0064, log rank test) compared to other gastric operations. Postoperative adjuvant treatment in general significantly prolonged the overall survival of stage IV patients (p=0.0017, log rank test).